"This web page was produced as an assignment for Genetics 564, an undergraduate capstone course at UW-Madison."
What is gene ontology?
Gene ontology (GO) is a common language used to describe the functions and processes of a gene or protein. Gene ontology has three properties: molecular function, cellular component, and biological process (1). These terms help explain the role and function of a protein, and how that function affects the cell.
Molecular function: molecular function describes how gene products control and function at the molecular level. This may include processes such as protein binding (1).
Cellular component: cellular component defines where in the cell the gene products are located and functioning. For example, gene products might be localized in the mitochondria or at the cellular membranes (1).
Biological process: biological process refers to the overall processes accomplished by the gene products and interactions between multiple gene products (1).
Molecular function: molecular function describes how gene products control and function at the molecular level. This may include processes such as protein binding (1).
Cellular component: cellular component defines where in the cell the gene products are located and functioning. For example, gene products might be localized in the mitochondria or at the cellular membranes (1).
Biological process: biological process refers to the overall processes accomplished by the gene products and interactions between multiple gene products (1).
Results
Alpha synuclein: Molecular function
alpha synuclein: cellular component
Alpha synuclein: Biological process
Discussion
Gene ontology can be used to help understand the localization and function of a protein. Gene ontology works by characterizing the molecular function, cellular component, and biological processes that a protein in which a protein is involved. Understanding the processes, or where a protein is localized in the cell, aids in understanding a gene or protein's normal function or role in a disease.
References
1. Ontology Documentation-Gene Ontology Consortium. (2018). Retrieved from http://geneontology.org/page/ontology-documentation
2. Parts of the Nerve Cell and Their Functions- Brain and Mind. Retrieved from http://www.cerebromente.org.br/n07/fundamentos/neuron/parts_i.htm
3. Neurotransmitters-Exploring the Brain. (2018). Retrieved from http://scienceofstudy.wikispaces.com/Neurotransmitters
4. Neurodegenerative diseases-German Research School for Simulation Sciences. Retrieved from http://www.grs-sim.de/research/computational-biophysics/research-activity/neurodegenerative-diseases.html
5. Gene Ontology Information- Retrieved from http://geneontology.org/
2. Parts of the Nerve Cell and Their Functions- Brain and Mind. Retrieved from http://www.cerebromente.org.br/n07/fundamentos/neuron/parts_i.htm
3. Neurotransmitters-Exploring the Brain. (2018). Retrieved from http://scienceofstudy.wikispaces.com/Neurotransmitters
4. Neurodegenerative diseases-German Research School for Simulation Sciences. Retrieved from http://www.grs-sim.de/research/computational-biophysics/research-activity/neurodegenerative-diseases.html
5. Gene Ontology Information- Retrieved from http://geneontology.org/