"This web page was produced as an assignment for Genetics 564, an undergraduate capstone course at UW-Madison."
introduction
What is transcriptomics?
Transcriptomics is the study of the complete set of gene transcripts by the genome (1). Transcriptomics helps predict and analyze gene expression. Transcriptomics can tell us where genes are turned on in specific cells or tissues. All genes are often present in each cell, but some genes my be turned off in one cell type, while they are turned on in another (1). By studying which genes are turned on or off in a cell, we can begin to understand the function of those genes (1).
What is a transcript?
In a process called the Central Dogma of biology, DNA is made into RNA transcripts through a process called transcription, which is subsequently made into a protein through translation. These processes require several different molecular machines, and these machines work together to control gene expression and activity.
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Results
Alpha Synuclein Expression Profile
According to the NCBI expression profiles and GEO datasets, triplication of alpha synuclein, when compared to wild type alpha synuclein, has been found to cause an aggressive form of Parkinson's disease in humans. These results allow for the alpha synuclein expression profiles to be linked to human disease.
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Discussion
Proper gene expression and regulation is imperative for maintaining normal cellular processes. Transcriptomics helps provide a link between transcripts, gene expression, and gene function, allowing for a deeper and more accurate understanding of genetic functions. It is clear that over-expression of the SNCA gene leads to complications that may accelerate the development of lewy bodies and neurodegenerative diseases.
References
1. Transcriptome-National Human Genome Research Institute. (2015). Retrieved from https://www.genome.gov/13014330/
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